PMC Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells. Free Radic Biol Med. Aims: To assess the protective effect of quercetin against DIC-induced liver toxicity in rats. However, quercetin has poor water solubility, so it cannot accumulate well in the liver. Found inside – Page 101Session 3-5 - Toxicity Studies Submission ID: 358 CYTOPROTECTIVE EFFECTS OF RHEUM RIBES RESVERATROL AND QUERCETININE TREATMENTS IN CCICREATED LIVER DAMAGE SEVGIYÜKSEK1, SEMA KAPTANOĞLU1, GÖKHAN OTO1 Corresponding Author: SEVGİ YÜKEK, ... This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. 1993 Sep;422:1-340. 20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment. Wang G, Wang JJ, Yang GY, Du SM, Zeng N, Li DS, Li RM, Chen JY, Feng JB, Yuan SH, Ye F. Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death. Dr. Group gives his list of the top 14 Foods to help cleanse the liver. The nanoparticles are stable in the form of freeze-dried powder for a long time storage and resuspend in 0.9% normal saline before experimental use. However, the limited solubility of quercetin in water and poor bioavailability in liver present a major problem for its administration as a chemopreventer. Finally, you can help detox your liver naturally through the quercetin-containing foods you eat. 2015;85:12–23. Found inside – Page 1150... through oral Arsenic-induced liver administration in fibrosis combination with Application in reducing either free or nano- arsenic-induced acute quercetin (2.7 mg/kg liver toxicity body weight) through intravenous injection. 2020 Dec 7;25(23):5772. doi: 10.3390/molecules25235772. 2018JJ2642). The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. a Size distribution of nanoliposomal quercetin; b Scanning electron microscopy image of nanoliposomal quercetin. Google Scholar. Zhang HY, Han DW, Zhao ZF, Liu MS, Wu YJ, Chen XM, Ji C. Multiple pathogenic factor-induced complications of cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia. Quercetin is known as a versatile molecule due to its vast clinical effects such as carcinogenic inhibition, decrease in cardiovascular diseases, anti-obesity effect, reduction of the risk of cataracts, protective effects against neurodegenerative diseases, intense antiviral effect on Dengue virus type II, bacteriostatic effect on some bacteria like E. coli and Salmonella, reduction of liver . The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism. Toxicity and carcinogenicity studies of quercetin were conducted in male and female F344/N rats, under conditions which allowed comparison to results of approximately 400 previously tested chemicals. Ji LL, Sheng YC, Zheng ZY, Shi L, Wang ZT. Similar to HCQ and CQ, quercetin also serves as a zinc ionophore. 2011 May;(565):1-177. Zhang YD, Wang JW, Liu XY, Zhao ZY, Zhang LH, Long B. Varshosaz J, Jafarian A, Salehi G, Zolfaghari B. Toxicity and carcinogenicity studies of quercetin were conducted in male and female F344/N rats, under conditions which allowed comparison to results of approximately 400 previously tested chemicals. Article Hepatology. Sections were stained by H&E staining and observed under a microscope for gross pathology evaluation. Prevention and treatment information (HHS). Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. At 1 day after the last drug injection, 2 mL blood per rat was obtained from the inferior vena cava for liver function detection, including serum levels of glutamic-pyruvic transaminase (GPT), glutamic-oxal acetic transaminase (GOT) and direct bilirubin (DBIL). We obtained 40 healthy Sprague-Dawley (SD) rats with half male and half female, 80 to 120 g body weight, from the experimental animal department of Xiangya Medical College of Central South University, and rats were kept under lab conditions (20–25 °C, 50% relative humidity, 12-h light-dark cycle). Mouse models of acute and chronic hepacivirus infection. Using liposomal nanoparticles to entrap quercetin might be an effective strategy to reduce hepatic injury and protect hepatocytes against damage. The authors declare that they have no competing interests. Canadian Journal of Physiology and Pharmacology, 96(6), 624-629. Ader, P., Wessmann, A., & Wolffram, S. (2000). How Does Quercetin Affect the Liver: Prevention is Key! Zhao X, Gong L, Wang C, Liu M, Hu N, Dai X, Peng C, Li Y. J Ethnopharmacol. Found inside – Page 141Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. Digestive Diseases and Sciences. 2003;48:824-829. DOI: 10.1023/A:1022869716643 [72] Najafzadeh H, Jalali MR, Morovvati H, Taravati F. Comparison ... Ren KW, Li YH, Wu G, Ren JZ, Lu HB, Li ZM, Han XW. Context: Diclofenac (DIC) is known for its anti-inflammatory and analgesic properties but liver toxicity is one of the main targets to use this drug. Interaction among phenols in food fortification: negative synergism on antioxidant capacity. It is one of the most abundant flavonoids in edible vegetables, fruit and wine. Wang X, Fang C, Tian S, Zhu X, Yang L, Huang Z, Li H, Dusp14 protects against hepatic ischemia-reperfusion injury via Tak1 suppression. 8600 Rockville Pike analgesic properties but liver toxicity is one of the main targets to use this drug. In a model of 4-hydroxynonenal-induced toxicity in H9c2 heart cell line quercetin pretreatment (0.1-10 µM for 24 hours) diminished production of reactive oxygen species, p-SAPK/JNK levels, p-Hsp27 levels, . Bethesda, MD 20894, Help The design of the study, collection, analysis, and interpretation of data was supported by the grant Hunan Provincial Natural Science Foundation of China (grant no. Our data indicate that treatment with nanoliposomal quercetin could reduce hepatic injury and protect hepatocytes against damage effectively. Found insideTherefore, they concluded that the protective effect of bixin against hepatotoxicity induced by CCl4 is related to the antioxidant activity of the compound. CAFFEIC ACID AND QUERCETIN Caffeic acid (CA) and quercetin, the well-known ... Can J Physiol Pharmacol. P < 0.05 was considered statistically significant. Please enable it to take advantage of the complete set of features! Nanoliposomal quercetin was prepared by the thin film evaporation method as described [15]. The chemical was administered in the feed for 2-years at concentrations of 0, 1000, 10,000, or 40,000 ppm, and the estimated dose delivered was approximately 40-1900 mg/kg/day. Moradpour D, Blum HE. Found insideOne of the interesting findings was how the quercetin was inhibiting liver damage. Other studies suggested that the accumulation of fat in the liver was linked to abnormal microorganisms being present in the colon and intestines—the ... Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds. Nat Rev Cancer. Quercetin belongs to a group of plant pigments called flavonoids that give many fruits, flowers, and vegetables their colors. Nutrients. 2018;37:42. DNAX activating protein of 12 kDa/triggering receptor expressed on myeloid cells 2 expression by mouse and human liver dendritic cells: functional implications and regulation of liver ischemia-reperfusion injury. 3c-d). Natl Toxicol Program Tech Rep Ser. Found inside – Page 298... activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats. ... Chen LJ, Wei YQ, Wang YS (2014) Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis ... 2020 Sep 3;21(17):6448. doi: 10.3390/ijms21176448. Mingmei Liao. 2019;70:696–710. Provides information on scientific and common names, characteristics, active compounds, clinical effects, indications, usage, clinical research, precautions, interactions, and dosage for over seven hundred herbs. In conclusion, quercetin is an effective liver protectant. Found inside – Page 245... I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. ... protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes. As compared with the other groups, hepatic-injured rats with saline treatment showed significantly decreased food intake, body weight and activity accompanied by poor light reactions. Simultaneously, rats were fed high-fat corn powder (79.5% pure corn powder with 10% lard and 0.5% cholesterol) and drank 10% ethanol as the only liquid every day. In the following experiments, the dose of nanoliposomal quercetin was based on the content of quercetin. Briefly, liposomes, containing with quercetin were prepared from phosphatidylcholine, phosphatidylserine and cholesterol (molar ratio: 5:1:1) by a modification of the thin film evaporation method. Hepatic sinusoids, interlobular arteries, interlobular veins and interlobular bile ducts in portal areas were normal. Natl Toxicol Program Tech Rep Ser. To determine the effect of nanoliposomal quercetin on liver function, we detected serum levels of GPT, GOT and DBIL by using GPT/GOT ELISA kit and bilirubin assay kit. Ahn, J., Lee, H., Kim, S., Park, J., & Ha, T. (2008). Quercetin is a plant pigment (flavonoid). After pure quercetin or nanoliposomal quercetin treatment, liver function was evaluated by detecting serum levels of glutamic-pyruvic transaminase (GPT), glutamic-oxal acetic transaminase (GOT) and direct bilirubin (DBIL). After the first subcutaneous injection, all groups were injected intraperitoneally with 0.9% normal saline for control and saline-treated rats and pure quercetin and nanoliposomal quercetin at 5 mg/100 g body weight in 0.2 mL once a day for 1 week, then every 2 days for 4 weeks for quercetin- and nanoliposomal quercetin-treated rats. This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Hepatocytes were arranged around the central vein in a single line and had a radial shape with no lesions. Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C. Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury. Bookshelf Natl Toxicol Program Tech Rep Ser. Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. 2005;17:477–83. Despite extensive research on understanding the mechanism of quercetin in the treatment of liver diseases, there are still no targeted therapies available. About 6 weeks later, all rats were killed after anesthesia, and blood and liver samples were collected for further analysis. : Flavonoid quercetin is widely found in the plant kingdom. In this study, we used liposomal nanoparticles to entrap quercetin and evaluated its protective and therapeutic effects on drug-induced liver . Found inside – Page 236alcohol-induced liver injury through reducing the activation of NF-κB or inducing the expression of heme ... stress in human hepatocytes;46 quercetin pretreatment also protects rats' liver from alcohol-induced oxidative damage.47 ... Gupta V, Sharma R, Bansal P, Kaur G. Bioactivity-guided isolation of potent anxiolytic compounds from leaves of Citrus paradisi. 1996 Aug;383:1-370. Rats were randomly divided into 4 groups (10 rats per group): normal control and 3 groups of hepatic-injured rats that received saline, quercetin, or nanoliposomal quercetin. Found inside – Page 265... while pycnogenol is weakly active (as compared to luteolin or quercetin) but could cause liver toxicity. As an additional consideration, the most common source of the flavonoid quercetin is fava beans, which can induce hemolytic ...
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